Endocrine Abstracts

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...

Erythropoietin (Epo) treatment has been shown to induce mitochondrial biogenesis in cardiac muscle along with enhanced mitochondrial capacity in mice. We hypothesized that recombinant human Epo (rhEpo) treatment enhances skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity in humans. In six healthy volunteers rhEpo was administered by s.c. injection over eight weeks with oral iron (100 mg) supplementation taken daily. Mitochondrial OXPHOS was quantified by...